Wikipedia: "While the tradition holds that the church was built over the prison of Pope Marcellus I (d. 309), it is known that the Titulus Marcelli
was already present in 418, when Pope Boniface I was elected here. The "Septiformis" litany, commanded by Pope Gregory I in 590, saw the men moving from San Marcello. Pope Adrian I, in the 8th century, built a church on the same place, which is currently under the modern church. The corpse of Cola di Rienzo, was held in the church for three days after his execution in 1354. On 22 May 1519 a fire destroyed the church. The money collected for its rebuilding was used to bribe the landsknechts
, who were pillaging the city during the Sack of Rome (1527). The original plan to rebuild the church was designed by Jacopo Sansovino, who fled the city during the Sack and never returned to finish it. The work was continued by Antonio da Sangallo the Younger, who rebuilt the church, but a Tiber flood damaged it again in 1530. It was only in 1592 that the church was completed, and later Carlo Fontana built the facade."
"The church is baroque in style and has a single nave with five chapels on each side. The gilded coffered ceiling dates from 1592, the gift of Mons. Giulio Vitelli, whose family coats of arms are depicted there. An image of the Virgin is in the center; other compartments have Marian symbols derived from the Litany of Loreto. The fourteen frescoes next to the windows in the nave depict scenes from our Lord's Passion and Resurrection and are by Giovanni Battista Ricci. His is also the huge "Crucifixion" (1613) on the rear wall over the entrance. Beneath the fresco, and left of the entrance door, is the monument to Cardinal Francesco Cenini (d. 1645), titular (1621-1645)." (Joseph N. Tylenda: The Pilgrim's Guide to Rome's Principal Churches, Kansas City 2010).